8/19/2023 0 Comments Color hunt use on tb![]() ![]() ![]() Overall agreement between TB-CX test and LJ DST for detection of MDR-TB was 93%. The specificity of the TB-CX test for detecting INH, RIF, and MDR-TB was 94%, 40%, and 94% respectively. The sensitivity of the TB-CX test to detect drug resistance to INH, RIF, and MDR-TB was 91%, 100%, and 90% respectively. The sensitivity and specificity of the TB-CX test for detecting M.tb were 94% and98%, respectively (concordance, 96% kappa 0.91). The TB-CX test detected M.tb and DST in an average of 13 days compared to 50 days for the conventional DST result. ![]() A total of 137 participants were analyzed: 88 (64%) were new TB cases, 49 (36%) were re-treatment cases. Kappa statistic was applied to test agreement between results for TB-CX test and the reference methods, a cut-off Kappa value of 0.75 was considered as high level of agreements. TB-CX test results were compared to reference Löwenstein-Jensen (LJ) culture for M.tb detection and DST for susceptibility to INH and RIF. All subjects received a GeneXpert MTB/RIF PCR test. Patients undergoing examination for TB and multidrug-resistant (MDR)-TB were enrolled in Addis Ababa, Ethiopia from March 2016 to February 2017. We evaluated the performance of a low technology, thin layer agar, Mycobacterium tuberculosis (M.tb) culture color plate (TB-CX) test with concurrent drug susceptibility testing (DST) to isoniazid (INH), rifampin (RIF), and pyrazinamide (PZA) directly from sputum specimens. Timely diagnosis of tuberculosis (TB) is limited in Ethiopia. ![]()
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